The molecular chaperone Brichos breaks the catalytic cycle that generates toxic Aβ oligomers

Alzheimer’s disease is an increasingly prevalent neurodegenerative disorder whose pathogenesis has been associated with aggregation of the amyloid-β peptide (Aβ42). Recent studies have revealed that once Aβ42 fibrils are generated, their surfaces strongly catalyse the formation of neurotoxic oligome...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Cohen, Samuel I. A., Arosio, Paolo, Presto, Jenny, Kurudenkandy, Firoz Roshan, Biverstal, Henrik, Dolfe, Lisa, Dunning, Christopher, Yang, Xiaoting, Frohm, Birgitta, Vendruscolo, Michele, Johansson, Jan, Dobson, Christopher M., Fisahn, André, Knowles, Tuomas P. J., Linse, Sara
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595974/
https://ncbi.nlm.nih.gov/pubmed/25686087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2971
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