Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state

Protein misfolding and aggregation is increasingly being recognized as a cause of disease. In Alzheimer’s disease the amyloid-β peptide (Aβ) misfolds into neurotoxic oligomers and assembles into amyloid fibrils. The Bri2 protein associated with Familial British and Danish dementias contains a BRICHO...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Chen, Gefei, Abelein, Axel, Nilsson, Harriet E., Leppert, Axel, Andrade-Talavera, Yuniesky, Tambaro, Simone, Hemmingsson, Lovisa, Roshan, Firoz, Landreh, Michael, Biverstål, Henrik, Koeck, Philip J. B., Presto, Jenny, Hebert, Hans, Fisahn, André, Johansson, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727130/
https://ncbi.nlm.nih.gov/pubmed/29234026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02056-4
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