Recombinant Bri3 BRICHOS domain is a molecular chaperone with effect against amyloid formation and non-fibrillar protein aggregation

Molecular chaperones assist proteins in achieving a functional structure and prevent them from misfolding into aggregates, including disease-associated deposits. The BRICHOS domain from familial dementia associated protein Bri2 (or ITM2B) probably chaperones its specific proprotein region with high...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Poska, Helen, Leppert, Axel, Tigro, Helene, Zhong, Xueying, Kaldmäe, Margit, Nilsson, Harriet E, Hebert, Hans, Chen, Gefei, Johansson, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299998/
https://ncbi.nlm.nih.gov/pubmed/32555390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66718-y
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