Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1(G93A) ALS mice: overlapping effects or limited therapeutic opportunity?

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease characterized by the loss of motoneurons (MNs) in the spinal cord, brainstem and motor cortex, causing progressive paralysis and death. Nowadays, there is no effective therapy and most patients die 2–5 years...

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Bibliografiske detaljer
Main Authors: Mancuso, Renzo, del Valle, Jaume, Morell, Marta, Pallás, Mercé, Osta, Rosario, Navarro, Xavier
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035830/
https://ncbi.nlm.nih.gov/pubmed/24885036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1172-9-78
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