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Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1(G93A) ALS mice: overlapping effects or limited therapeutic opportunity?
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease characterized by the loss of motoneurons (MNs) in the spinal cord, brainstem and motor cortex, causing progressive paralysis and death. Nowadays, there is no effective therapy and most patients die 2–5 years...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BioMed Central
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4035830/ https://ncbi.nlm.nih.gov/pubmed/24885036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1172-9-78 |
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