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Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1(G93A) ALS mice: overlapping effects or limited therapeutic opportunity?

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease characterized by the loss of motoneurons (MNs) in the spinal cord, brainstem and motor cortex, causing progressive paralysis and death. Nowadays, there is no effective therapy and most patients die 2–5 years...

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Detalhes bibliográficos
Main Authors: Mancuso, Renzo, del Valle, Jaume, Morell, Marta, Pallás, Mercé, Osta, Rosario, Navarro, Xavier
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035830/
https://ncbi.nlm.nih.gov/pubmed/24885036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1172-9-78
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