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Robust and accurate prediction of residue–residue interactions across protein interfaces using evolutionary information

Do the amino acid sequence identities of residues that make contact across protein interfaces covary during evolution? If so, such covariance could be used to predict contacts across interfaces and assemble models of biological complexes. We find that residue pairs identified using a pseudo-likeliho...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Ovchinnikov, Sergey, Kamisetty, Hetunandan, Baker, David
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: eLife Sciences Publications, Ltd 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034769/
https://ncbi.nlm.nih.gov/pubmed/24842992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02030
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