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Robust and accurate prediction of residue–residue interactions across protein interfaces using evolutionary information

Do the amino acid sequence identities of residues that make contact across protein interfaces covary during evolution? If so, such covariance could be used to predict contacts across interfaces and assemble models of biological complexes. We find that residue pairs identified using a pseudo-likeliho...

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Hlavní autoři: Ovchinnikov, Sergey, Kamisetty, Hetunandan, Baker, David
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034769/
https://ncbi.nlm.nih.gov/pubmed/24842992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02030
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