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Origins of coevolution between residues distant in protein 3D structures

Residue pairs that directly coevolve in protein families are generally close in protein 3D structures. Here we study the exceptions to this general trend—directly coevolving residue pairs that are distant in protein structures—to determine the origins of evolutionary pressure on spatially distant re...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Anishchenko, Ivan, Ovchinnikov, Sergey, Kamisetty, Hetunandan, Baker, David
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576787/
https://ncbi.nlm.nih.gov/pubmed/28784799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702664114
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