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Origins of coevolution between residues distant in protein 3D structures

Residue pairs that directly coevolve in protein families are generally close in protein 3D structures. Here we study the exceptions to this general trend—directly coevolving residue pairs that are distant in protein structures—to determine the origins of evolutionary pressure on spatially distant re...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Anishchenko, Ivan, Ovchinnikov, Sergey, Kamisetty, Hetunandan, Baker, David
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576787/
https://ncbi.nlm.nih.gov/pubmed/28784799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702664114
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