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Origins of coevolution between residues distant in protein 3D structures

Residue pairs that directly coevolve in protein families are generally close in protein 3D structures. Here we study the exceptions to this general trend—directly coevolving residue pairs that are distant in protein structures—to determine the origins of evolutionary pressure on spatially distant re...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Anishchenko, Ivan, Ovchinnikov, Sergey, Kamisetty, Hetunandan, Baker, David
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576787/
https://ncbi.nlm.nih.gov/pubmed/28784799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702664114
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