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Origins of coevolution between residues distant in protein 3D structures

Residue pairs that directly coevolve in protein families are generally close in protein 3D structures. Here we study the exceptions to this general trend—directly coevolving residue pairs that are distant in protein structures—to determine the origins of evolutionary pressure on spatially distant re...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Anishchenko, Ivan, Ovchinnikov, Sergey, Kamisetty, Hetunandan, Baker, David
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5576787/
https://ncbi.nlm.nih.gov/pubmed/28784799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702664114
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