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Assessing the utility of coevolution-based residue–residue contact predictions in a sequence- and structure-rich era

Recently developed methods have shown considerable promise in predicting residue–residue contacts in protein 3D structures using evolutionary covariance information. However, these methods require large numbers of evolutionarily related sequences to robustly assess the extent of residue covariation,...

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Detalhes bibliográficos
Main Authors: Kamisetty, Hetunandan, Ovchinnikov, Sergey, Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785744/
https://ncbi.nlm.nih.gov/pubmed/24009338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314045110
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