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Assessing the utility of coevolution-based residue–residue contact predictions in a sequence- and structure-rich era

Recently developed methods have shown considerable promise in predicting residue–residue contacts in protein 3D structures using evolutionary covariance information. However, these methods require large numbers of evolutionarily related sequences to robustly assess the extent of residue covariation,...

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Hlavní autoři: Kamisetty, Hetunandan, Ovchinnikov, Sergey, Baker, David
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785744/
https://ncbi.nlm.nih.gov/pubmed/24009338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314045110
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