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Assessing the utility of coevolution-based residue–residue contact predictions in a sequence- and structure-rich era

Recently developed methods have shown considerable promise in predicting residue–residue contacts in protein 3D structures using evolutionary covariance information. However, these methods require large numbers of evolutionarily related sequences to robustly assess the extent of residue covariation,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kamisetty, Hetunandan, Ovchinnikov, Sergey, Baker, David
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785744/
https://ncbi.nlm.nih.gov/pubmed/24009338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314045110
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