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Assessing the utility of coevolution-based residue–residue contact predictions in a sequence- and structure-rich era

Recently developed methods have shown considerable promise in predicting residue–residue contacts in protein 3D structures using evolutionary covariance information. However, these methods require large numbers of evolutionarily related sequences to robustly assess the extent of residue covariation,...

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Bibliografske podrobnosti
Main Authors: Kamisetty, Hetunandan, Ovchinnikov, Sergey, Baker, David
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785744/
https://ncbi.nlm.nih.gov/pubmed/24009338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314045110
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