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Ku80-deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response

Ku80 facilitates DNA repair and therefore should suppress cancer. However, ku80−/− mice exhibit reduced cancer, although they age prematurely and have a shortened life span. We tested the hypothesis that Ku80 deletion suppresses cancer by enhancing cellular tumor suppressive responses to inefficient...

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Bibliografische gegevens
Hoofdauteurs: Holcomb, Valerie B., Rodier, Francis, Choi, Yong Jun, Busuttil, Rita A., Vogel, Hannes, Vijg, Jan, Campisi, Judith, Hasty, Paul
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034752/
https://ncbi.nlm.nih.gov/pubmed/19010925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2085
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