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Deletion of Ku70, Ku80, or Both Causes Early Aging without Substantially Increased Cancer
Ku70 forms a heterodimer with Ku80, called Ku, that is critical for repairing DNA double-stand breaks by nonhomologous end joining and for maintaining telomeres. Mice with either gene mutated exhibit similar phenotypes that include increased sensitivity to ionizing radiation and severe combined immu...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2169178/ https://ncbi.nlm.nih.gov/pubmed/17875923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00785-07 |
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