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Ku80-Deleted Cells are Defective at Base Excision Repair

Ku80 forms a heterodimer with Ku70, called Ku, that repairs DNA double-strand breaks (DSBs) via the nonhomologous end joining (NHEJ) pathway. As a consequence of deleting NHEJ, Ku80-mutant cells are hypersensitive to agents that cause DNA DSBs like ionizing radiation. Here we show that Ku80 deletion...

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Bibliografische gegevens
Hoofdauteurs: Li, Han, Marple, Teresa, Hasty, Paul
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3721509/
https://ncbi.nlm.nih.gov/pubmed/23567907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2013.03.010
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