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Ku80-Deleted Cells are Defective at Base Excision Repair
Ku80 forms a heterodimer with Ku70, called Ku, that repairs DNA double-strand breaks (DSBs) via the nonhomologous end joining (NHEJ) pathway. As a consequence of deleting NHEJ, Ku80-mutant cells are hypersensitive to agents that cause DNA DSBs like ionizing radiation. Here we show that Ku80 deletion...
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| Hoofdauteurs: | , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3721509/ https://ncbi.nlm.nih.gov/pubmed/23567907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrfmmm.2013.03.010 |
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