Defects in Base Excision Repair Sensitize Cells to Manganese in S. cerevisiae

Manganese (Mn) is essential for normal physiologic functioning; therefore, deficiencies and excess intake of manganese can result in disease. In humans, prolonged exposure to manganese causes neurotoxicity characterized by Parkinson-like symptoms. Mn(2+) has been shown to mediate DNA damage possibly...

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Detalhes bibliográficos
Main Authors: Stephenson, Adrienne P., Mazu, Tryphon K., Miles, Jana S., Freeman, Miles D., Reams, R. Renee, Flores-Rozas, Hernan
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3825218/
https://ncbi.nlm.nih.gov/pubmed/24282812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/295635
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