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Deletion of Ku80 Causes Early Aging Independent of Chronic Inflammation and Rag-1-Induced DSBs
Animal models of premature aging are often defective for DNA repair. Ku80-mutant mice are disabled for nonhomologous end joining; a pathway that repairs both spontaneous DNA double-strand breaks (DSBs) and induced DNA DSBs generated by the action of a complex composed of Rag-1 and Rag-2 (Rag). Rag i...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692937/ https://ncbi.nlm.nih.gov/pubmed/17928034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2007.08.006 |
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