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Deletion of Ku80 Causes Early Aging Independent of Chronic Inflammation and Rag-1-Induced DSBs

Animal models of premature aging are often defective for DNA repair. Ku80-mutant mice are disabled for nonhomologous end joining; a pathway that repairs both spontaneous DNA double-strand breaks (DSBs) and induced DNA DSBs generated by the action of a complex composed of Rag-1 and Rag-2 (Rag). Rag i...

詳細記述

保存先:
書誌詳細
主要な著者: Holcomb, Valerie B., Vogel, Hannes, Hasty, Paul
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692937/
https://ncbi.nlm.nih.gov/pubmed/17928034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2007.08.006
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