Effect of Ku80 Deficiency on Mutation Frequencies and Spectra at a LacZ Reporter Locus in Mouse Tissues and Cells

Non-homologous end joining (NHEJ) is thought to be an important mechanism for preventing the adverse effects of DNA double strand breaks (DSBs) and its absence has been associated with premature aging. To investigate the effect of inactivated NHEJ on spontaneous mutation frequencies and spectra in v...

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Detalhes bibliográficos
Main Authors: Busuttil, Rita A., Muñoz, Denise P., Garcia, Ana Maria, Rodier, Francis, Kim, Woo Ho, Suh, Yousin, Hasty, Paul, Campisi, Judith, Vijg, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565499/
https://ncbi.nlm.nih.gov/pubmed/18941635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003458
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