Effect of Ku80 Deficiency on Mutation Frequencies and Spectra at a LacZ Reporter Locus in Mouse Tissues and Cells

Non-homologous end joining (NHEJ) is thought to be an important mechanism for preventing the adverse effects of DNA double strand breaks (DSBs) and its absence has been associated with premature aging. To investigate the effect of inactivated NHEJ on spontaneous mutation frequencies and spectra in v...

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Detaylı Bibliyografya
Asıl Yazarlar: Busuttil, Rita A., Muñoz, Denise P., Garcia, Ana Maria, Rodier, Francis, Kim, Woo Ho, Suh, Yousin, Hasty, Paul, Campisi, Judith, Vijg, Jan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2008
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565499/
https://ncbi.nlm.nih.gov/pubmed/18941635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003458
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