Potent and Selective Inhibitors of Human Reticulocyte 12/15-Lipoxygenase as Anti-Stroke Therapies

[Image: see text] A key challenge facing drug discovery today is variability of the drug target between species, such as with 12/15-lipoxygenase (12/15-LOX), which contributes to ischemic brain injury, but its human and rodent isozymes have different inhibitor specificities. In the current work, we...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Rai, Ganesha, Joshi, Netra, Jung, Joo Eun, Liu, Yu, Schultz, Lena, Yasgar, Adam, Perry, Steve, Diaz, Giovanni, Zhang, Qiangli, Kenyon, Victor, Jadhav, Ajit, Simeonov, Anton, Lo, Eng H., van Leyen, Klaus, Maloney, David J., Holman, Theodore R.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Chemical Society 2014
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033661/
https://ncbi.nlm.nih.gov/pubmed/24684213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401915r
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