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Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegans

DNA lesions that block replication fork progression are drivers of cancer-associated genome alterations, but the error-prone DNA repair mechanisms acting on collapsed replication are incompletely understood, and their contribution to genome evolution largely unexplored. Here, through whole-genome se...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Roerink, Sophie F., van Schendel, Robin, Tijsterman, Marcel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032859/
https://ncbi.nlm.nih.gov/pubmed/24614976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.170431.113
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