The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis

BACKGROUND: Osteosarcoma is the most frequent primary malignant bone tumor, notorious for its lung metastasis. Shikonin, an effective constituent extracted from Chinese medicinal herb, was demonstrated to induce necroptosis in some cancers. METHODS: MTT assay was performed to detect cell survival ra...

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Bibliografski detalji
Glavni autori: Fu, Zeze, Deng, Biyong, Liao, Yuxin, Shan, Liancheng, Yin, Fei, Wang, Zhuoying, Zeng, Hui, Zuo, Dongqing, Hua, Yingqi, Cai, Zhengdong
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028842/
https://ncbi.nlm.nih.gov/pubmed/24314238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-580
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