The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis

BACKGROUND: Osteosarcoma is the most frequent primary malignant bone tumor, notorious for its lung metastasis. Shikonin, an effective constituent extracted from Chinese medicinal herb, was demonstrated to induce necroptosis in some cancers. METHODS: MTT assay was performed to detect cell survival ra...

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Autori principali: Fu, Zeze, Deng, Biyong, Liao, Yuxin, Shan, Liancheng, Yin, Fei, Wang, Zhuoying, Zeng, Hui, Zuo, Dongqing, Hua, Yingqi, Cai, Zhengdong
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028842/
https://ncbi.nlm.nih.gov/pubmed/24314238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-580
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