The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis

BACKGROUND: Osteosarcoma is the most frequent primary malignant bone tumor, notorious for its lung metastasis. Shikonin, an effective constituent extracted from Chinese medicinal herb, was demonstrated to induce necroptosis in some cancers. METHODS: MTT assay was performed to detect cell survival ra...

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Библиографические подробности
Главные авторы: Fu, Zeze, Deng, Biyong, Liao, Yuxin, Shan, Liancheng, Yin, Fei, Wang, Zhuoying, Zeng, Hui, Zuo, Dongqing, Hua, Yingqi, Cai, Zhengdong
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028842/
https://ncbi.nlm.nih.gov/pubmed/24314238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-580
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