Shikonin induces glioma cell necroptosis in vitro by ROS overproduction and promoting RIP1/RIP3 necrosome formation

Necroptosis is a type of programmed necrosis regulated by receptor interacting protein kinase 1 (RIP1) and RIP3. Necroptosis is found to be accompanied by an overproduction of reactive oxygen species (ROS), but the role of ROS in regulation of necroptosis remains elusive. In this study, we investiga...

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Veröffentlicht in:Acta Pharmacol Sin
Hauptverfasser: LU, Bin, GONG, Xu, WANG, Zong-qi, DING, Ye, WANG, Chen, LUO, Tian-fei, PIAO, Mei-hua, MENG, Fan-kai, CHI, Guang-fan, LUO, Yi-nan, GE, Peng-fei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672068/
https://ncbi.nlm.nih.gov/pubmed/28816233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.112
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