Shikonin induces glioma cell necroptosis in vitro by ROS overproduction and promoting RIP1/RIP3 necrosome formation

Necroptosis is a type of programmed necrosis regulated by receptor interacting protein kinase 1 (RIP1) and RIP3. Necroptosis is found to be accompanied by an overproduction of reactive oxygen species (ROS), but the role of ROS in regulation of necroptosis remains elusive. In this study, we investiga...

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Detalles Bibliográficos
Publicado en:Acta Pharmacol Sin
Main Authors: LU, Bin, GONG, Xu, WANG, Zong-qi, DING, Ye, WANG, Chen, LUO, Tian-fei, PIAO, Mei-hua, MENG, Fan-kai, CHI, Guang-fan, LUO, Yi-nan, GE, Peng-fei
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672068/
https://ncbi.nlm.nih.gov/pubmed/28816233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.112
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