RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

Necroptosis is a type of programmed cell death with great significance in many pathological processes. Tumour necrosis factor-α(TNF), a proinflammatory cytokine, is a prototypic trigger of necroptosis. It is known that mitochondrial reactive oxygen species (ROS) promote necroptosis, and that kinase...

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Udgivet i:Nat Commun
Main Authors: Zhang, Yingying, Su, Sheng Sean, Zhao, Shubo, Yang, Zhentao, Zhong, Chuan-Qi, Chen, Xin, Cai, Qixu, Yang, Zhang-Hua, Huang, Deli, Wu, Rui, Han, Jiahuai
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309790/
https://ncbi.nlm.nih.gov/pubmed/28176780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14329
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