The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

RIP1 and RIP3 kinases are central players in TNF-induced programmed necrosis. Here, we report that the RIP homotypic interaction motifs (RHIMs) of RIP1 and RIP3 mediate the assembly of heterodimeric filamentous structures. The fibrils exhibit classical characteristics of β-amyloids, as shown by Thio...

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Détails bibliographiques
Auteurs principaux: Li, Jixi, McQuade, Thomas, Siemer, Ansgar B., Napetschnig, Johanna, Moriwaki, Kenta, Hsiao, Yu-Shan, Damko, Ermelinda, Moquin, David, Walz, Thomas, McDermott, Ann, Ka-Ming Chan, Francis, Wu, Hao
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664196/
https://ncbi.nlm.nih.gov/pubmed/22817896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.06.019
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