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Shikonin Kills Glioma Cells through Necroptosis Mediated by RIP-1

BACKGROUND AND PURPOSE: Shikonin was reported to induce necroptosis in leukemia cells, but apoptosis in glioma cell lines. Thus, it is needed to clarify whether shikonin could cause necroptosis in glioma cells and investigate its underlying mechanisms. METHODS: Shikonin and rat C6 glioma cell line a...

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Detalhes bibliográficos
Principais autores: Huang, Chuanjiang, Luo, Yinan, Zhao, Jingwei, Yang, Fuwei, Zhao, Hongwei, Fan, Wenhai, Ge, Pengfei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695975/
https://ncbi.nlm.nih.gov/pubmed/23840441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066326
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