Silencing of MGMT expression by promoter hypermethylation in the metaplasia–dysplasia–carcinoma sequence of Barrett’s esophagus

To determine the relevance of MGMT in Barrett’s carcinogenesis, we analyzed promotor hypermethylation and expression of MGMT in Barrett’s adenocarcinomas and its paired precursor lesions from 133 patients using a methylation-specific PCR, real-time RT-PCR and immunohistochemistry. Hypermethylation w...

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Detaylı Bibliyografya
Asıl Yazarlar: Kuester, Doerthe, El-Rifai, Wa’el, Peng, DunFa, Ruemmele, Petra, Kroeckel, Ivonne, Peters, Brigitte, Moskaluk, Christopher A., Stolte, Manfred, Mönkemüller, Klaus, Meyer, Frank, Schulz, Hans-Ulrich, Hartmann, Arndt, Roessner, Albert, Schneider-Stock, Regine
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028828/
https://ncbi.nlm.nih.gov/pubmed/19027227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2008.10.009
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