Hypermethylation, Loss of Expression of Glutathione Peroxidase-3 in Barrett's Tumorigenesis

Chronic gastroesophageal reflux disease is a known risk factor for Barrett's esophagus (BE), that induces oxidative mucosal damage. Glutathione peroxidase-3 (GPx3) is a secretory protein with potent extracellular antioxidant activity. Herein, we have investigated the mRNA, protein expression of...

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Detalhes bibliográficos
Main Authors: Ok-Jae Lee, Regine Schneider-Stock, Patricia A. McChesney, Doerthe Kuester, Albert Roessner, Michael Vieth, Christopher A. Moskaluk, Wa'el El-Rifai
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2005-09-01
Colecção:Neoplasia: An International Journal for Oncology Research
Assuntos:
Barrett's
dysplasia
cancer
GPx3
ROS
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1476558605800077
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