Silencing of MGMT expression by promoter hypermethylation in the metaplasia–dysplasia–carcinoma sequence of Barrett’s esophagus

To determine the relevance of MGMT in Barrett’s carcinogenesis, we analyzed promotor hypermethylation and expression of MGMT in Barrett’s adenocarcinomas and its paired precursor lesions from 133 patients using a methylation-specific PCR, real-time RT-PCR and immunohistochemistry. Hypermethylation w...

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Hlavní autoři: Kuester, Doerthe, El-Rifai, Wa’el, Peng, DunFa, Ruemmele, Petra, Kroeckel, Ivonne, Peters, Brigitte, Moskaluk, Christopher A., Stolte, Manfred, Mönkemüller, Klaus, Meyer, Frank, Schulz, Hans-Ulrich, Hartmann, Arndt, Roessner, Albert, Schneider-Stock, Regine
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028828/
https://ncbi.nlm.nih.gov/pubmed/19027227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2008.10.009
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