Silencing of MGMT expression by promoter hypermethylation in the metaplasia–dysplasia–carcinoma sequence of Barrett’s esophagus

To determine the relevance of MGMT in Barrett’s carcinogenesis, we analyzed promotor hypermethylation and expression of MGMT in Barrett’s adenocarcinomas and its paired precursor lesions from 133 patients using a methylation-specific PCR, real-time RT-PCR and immunohistochemistry. Hypermethylation w...

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Bibliografische gegevens
Hoofdauteurs: Kuester, Doerthe, El-Rifai, Wa’el, Peng, DunFa, Ruemmele, Petra, Kroeckel, Ivonne, Peters, Brigitte, Moskaluk, Christopher A., Stolte, Manfred, Mönkemüller, Klaus, Meyer, Frank, Schulz, Hans-Ulrich, Hartmann, Arndt, Roessner, Albert, Schneider-Stock, Regine
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028828/
https://ncbi.nlm.nih.gov/pubmed/19027227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2008.10.009
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