The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy

It is well known that the activation of Aurora A/B (Aur A/B) or inactivation of BRCA1/2 induces tumor formation. Others and we have reported that the mutual suppression between Aur A/B and BRCA1/2 may manipulate cancer cell growth and tumorigenesis, however, the interactive regulation and mechanism...

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Detalhes bibliográficos
Main Authors: Wang, Yan, Wang, Ziliang, Qi, Zihao, Yin, Sheng, Zhang, Na, Liu, Yang, Liu, Mingming, Meng, Jiao, Zang, Rongyu, Zhang, Zhen, Yang, Gong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028103/
https://ncbi.nlm.nih.gov/pubmed/24775809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-94
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