Interplay among BRCA1, SIRT1 and Survivin during BRCA1-Associated Tumorigenesis

Germline mutations of BRCA1 predispose women to breast and ovarian cancers. However, the downstream mediators of BRCA1 function in tumor suppression remain elusive. We found that human BRCA1-associated breast cancers have lower levels of SIRT1 than their normal controls. We further demonstrated that...

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Detalhes bibliográficos
Main Authors: Wang, Rui-Hong, Zheng, Yin, Kim, Hyun-Seok, Xu, Xiaoling, Cao, Liu, Lahusen, Tyler, Lee, Mi-Hye, Xiao, Cuiying, Vassilopoulos, Athanassios, Chen, Weiping, Gardner, Kevin, Man, Yan-Gao, Hung, Mien-Chie, Finkel, Toren, Deng, Chu-Xia
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577018/
https://ncbi.nlm.nih.gov/pubmed/18851829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.09.011
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