Hepatic specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis

Under various conditions mammals have the ability to maintain serum glucose concentration within a narrow range. SIRT1 plays an important role in regulating gluconeogenesis and fat metabolism; however, the underlying mechanisms remain elusive. Here we show that SIRT1 forms a complex with FOXO3a and...

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Detalhes bibliográficos
Main Authors: Kim, Hyun-Seok, Xiao, Cuiying, Wang, Rui-Hong, Lahusen, Tyler, Xu, Xiaoling, Vassilopoulos, Athanassios, Vazquez-Ortiz, Guelaguetza, Jeong, Won-Il, Park, Ogyi, Ki, Sung Hwan, Gao, Bin, Deng, Chu-Xia
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935915/
https://ncbi.nlm.nih.gov/pubmed/20816089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.06.009
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