Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis

While Aurora-A (Aur A) provokes, BRCA2 restrains primary tumorigenesis, the roles of Aur A and BRCA2 in cancer metastasis remains unclear. Here, we show that the metastatic promoting markers SLUG, FBN1, and MMP2, 9, 13 are either stimulated or suppressed by Aur A or BRCA2, but the metastatic suppres...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wang, Ziliang, Liu, Yang, Lu, Lili, Yang, Lina, Yin, Sheng, Wang, Yan, Qi, Zihao, Meng, Jiao, Zang, Rongyu, Yang, Gong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466642/
https://ncbi.nlm.nih.gov/pubmed/25749384
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