Aurora Kinase A Promotes Ovarian Tumorigenesis through Dysregulation of the Cell Cycle and Suppression of BRCA2

PURPOSE: Aurora kinase A (Aurora-A) is known to regulate genomic instability and tumorigenesis in multiple human cancers. The underlying mechanism, however, is not fully understood. We examined the molecular mechanism of Aurora-A regulation in human ovarian cancer. EXPERIMENTAL DESIGN: Retrovirus-me...

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Detalhes bibliográficos
Main Authors: Yang, Gong, Chang, Bin, Yang, Fan, Guo, Xiaoqing, Cai, Kathy Qi, Xiao, Xue (Sherry), Wang, Huamin, Sen, Subrata, Hung, Mien-Chie, Mills, Gordon B., Chang, Sandy, Multani, Asha S., Mercado-Uribe, Imelda, Liu, Jinsong
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930838/
https://ncbi.nlm.nih.gov/pubmed/20423983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-3171
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