Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis

[Image: see text] Potent inhibitors of RIP1 kinase from three distinct series, 1-aminoisoquinolines, pyrrolo[2,3-b]pyridines, and furo[2,3-d]pyrimidines, all of the type II class recognizing a DLG-out inactive conformation, were identified from screening of our in-house kinase focused sets. An exemp...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Harris, Philip A., Bandyopadhyay, Deepak, Berger, Scott B., Campobasso, Nino, Capriotti, Carol A., Cox, Julie A., Dare, Lauren, Finger, Joshua N., Hoffman, Sandra J., Kahler, Kirsten M., Lehr, Ruth, Lich, John D., Nagilla, Rakesh, Nolte, Robert T., Ouellette, Michael T., Pao, Christina S., Schaeffer, Michelle C., Smallwood, Angela, Sun, Helen H., Swift, Barbara A., Totoritis, Rachel D., Ward, Paris, Marquis, Robert W., Bertin, John, Gough, Peter J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2013
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027519/
https://ncbi.nlm.nih.gov/pubmed/24900635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400382p
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares