Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer

[Image: see text] RIP1 regulates cell death and inflammation and is believed to play an important role in contributing to a variety of human pathologies, including immune-mediated inflammatory diseases and cancer. While small-molecule inhibitors of RIP1 kinase have been advanced to the clinic for in...

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Publicat a:ACS Med Chem Lett
Autors principals: Harris, Philip A., Marinis, Jill M., Lich, John D., Berger, Scott B., Chirala, Anirudh, Cox, Julie A., Eidam, Patrick M., Finger, Joshua N., Gough, Peter J., Jeong, Jae U., Kang, James, Kasparcova, Viera, Leister, Lara K., Mahajan, Mukesh K., Miller, George, Nagilla, Rakesh, Ouellette, Michael T., Reilly, Michael A., Rendina, Alan R., Rivera, Elizabeth J., Sun, Helen H., Thorpe, James H., Totoritis, Rachel D., Wang, Wei, Wu, Dongling, Zhang, Daohua, Bertin, John, Marquis, Robert W.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580371/
https://ncbi.nlm.nih.gov/pubmed/31223438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00108
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