Characterization of GSK′963: a structurally distinct, potent and selective inhibitor of RIP1 kinase

Necroptosis and signaling regulated by RIP1 kinase activity is emerging as a key driver of inflammation in a variety of disease settings. A significant amount has been learned about how RIP1 regulates necrotic cell death through the use of the RIP1 kinase inhibitor Necrostatin-1 (Nec-1). Nec-1 has b...

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Dettagli Bibliografici
Pubblicato in:Cell Death Discov
Autori principali: Berger, SB, Harris, P, Nagilla, R, Kasparcova, V, Hoffman, S, Swift, B, Dare, L, Schaeffer, M, Capriotti, C, Ouellette, M, King, BW, Wisnoski, D, Cox, J, Reilly, M, Marquis, RW, Bertin, J, Gough, PJ
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979471/
https://ncbi.nlm.nih.gov/pubmed/27551444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2015.9
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