Characterization of GSK′963: a structurally distinct, potent and selective inhibitor of RIP1 kinase

Necroptosis and signaling regulated by RIP1 kinase activity is emerging as a key driver of inflammation in a variety of disease settings. A significant amount has been learned about how RIP1 regulates necrotic cell death through the use of the RIP1 kinase inhibitor Necrostatin-1 (Nec-1). Nec-1 has b...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Discov
Egile Nagusiak: Berger, SB, Harris, P, Nagilla, R, Kasparcova, V, Hoffman, S, Swift, B, Dare, L, Schaeffer, M, Capriotti, C, Ouellette, M, King, BW, Wisnoski, D, Cox, J, Reilly, M, Marquis, RW, Bertin, J, Gough, PJ
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979471/
https://ncbi.nlm.nih.gov/pubmed/27551444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2015.9
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak