RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice

RIP1 kinase is a key regulator of TNF-induced NFκB activation, apoptosis and necroptosis through its kinase and scaffolding activities. Dissecting the balance of RIP1 kinase activity and scaffolding function in vivo during development and TNF-dependent inflammation has been hampered by the perinatal...

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Autori principali: Berger, Scott B., Kasparcova, Viera, Hoffman, Sandy, Swift, Barb, Dare, Lauren, Schaeffer, Michelle, Capriotti, Carol, Cook, Michael, Finger, Joshua, Hughes-Earle, Angela, Harris, Philip A., Kaiser, William J., Mocarski, Edward S., Bertin, John, Gough, Peter J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048763/
https://ncbi.nlm.nih.gov/pubmed/24821972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400499
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