Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis

Necroptosis is mediated by a signaling complex called necrosome, containing receptor-interacting protein (RIP)1, RIP3, and mixed-lineage kinase domain-like (MLKL). It is known that RIP1 and RIP3 form heterodimeric filamentous scaffold in necrosomes through their RIP homotypic interaction motif (RHIM...

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Bibliographische Detailangaben
Hauptverfasser: Wu, X-N, Yang, Z-H, Wang, X-K, Zhang, Y, Wan, H, Song, Y, Chen, X, Shao, J, Han, J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211369/
https://ncbi.nlm.nih.gov/pubmed/24902902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.77
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