RIP3-mediated necroptosis is regulated by inter-filament assembly of RIP homotypic interaction motif

Necroptosis is mediated by signaling complexes called necrosomes, which contain receptor-interacting protein 3 (RIP3) and upstream effectors, such as RIP1. In necrosomes, the RIP homotypic interaction motif (RHIM) of RIP3 and RIP1 forms amyloidal complex. But how the amyloidal necrosomes control RIP...

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Pubblicato in:Cell Death Differ
Autori principali: Hu, Hong, Wu, Xialian, Wu, Guoxiang, Nan, Ning, Zhang, Jing, Zhu, Xinxin, Zhang, Yu, Shu, Zhaoqian, Liu, Jia, Liu, Xiaoyan, Lu, Junxia, Wang, Huayi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7853141/
https://ncbi.nlm.nih.gov/pubmed/32737444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-0598-9
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