A Structurally Simplified Analogue of Geldanamycin Exhibits Neuroprotective Activity

[Image: see text] The syntheses of a structurally simplified geldanamycin analogue 2 and two related compounds are described. Compound 2 conferred cytoprotection and quenched ROS and lipid peroxidation in a dose-dependent manner in Friedreich’s ataxia (FRDA) lymphocytes at low micromolar concentrati...

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Main Authors: Madathil, Manikandadas M., Khdour, Omar M., Jaruvangsanti, Jennifer, Hecht, Sidney M.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2013
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027499/
https://ncbi.nlm.nih.gov/pubmed/24900591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400207m
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