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A Structurally Simplified Analogue of Geldanamycin Exhibits Neuroprotective Activity
[Image: see text] The syntheses of a structurally simplified geldanamycin analogue 2 and two related compounds are described. Compound 2 conferred cytoprotection and quenched ROS and lipid peroxidation in a dose-dependent manner in Friedreich’s ataxia (FRDA) lymphocytes at low micromolar concentrati...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Chemical Society
2013
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027499/ https://ncbi.nlm.nih.gov/pubmed/24900591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400207m |
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