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Pazopanib and HDAC inhibitors interact to kill sarcoma cells

The present studies were to determine whether the multi-kinase inhibitor pazopanib interacted with histone deacetylase inhibitors (HDACI: valproate, vorinostat) to kill sarcoma cells. In multiple sarcoma cell lines, at clinically achievable doses, pazopanib and HDACI interacted in an additive to gre...

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Hlavní autoři: Tavallai, Seyedmehrad, Hamed, Hossein A, Grant, Steven, Poklepovic, Andrew, Dent, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026080/
https://ncbi.nlm.nih.gov/pubmed/24556916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.28163
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