Synthesis and Biochemical Evaluation of Thiochromanone Thiosemicarbazone Analogues as Inhibitors of Cathepsin L

[Image: see text] A series of 36 thiosemicarbazone analogues containing the thiochromanone molecular scaffold functionalized primarily at the C-6 position were prepared by chemical synthesis and evaluated as inhibitors of cathepsins L and B. The most promising inhibitors from this group are selectiv...

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Detalhes bibliográficos
Main Authors: Song, Jiangli, Jones, Lindsay M., Kumar, G. D. Kishore, Conner, Elizabeth S., Bayeh, Liela, Chavarria, Gustavo E., Charlton-Sevcik, Amanda K., Chen, Shen-En, Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025852/
https://ncbi.nlm.nih.gov/pubmed/24900494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200299g
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