Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators

[Image: see text] Grounding on our former 3D QSAR studies, a knowledge-based screen of natural bile acids from diverse animal species has led to the identification of avicholic acid as a selective but weak TGR5 agonist. Chemical modifications of this compound resulted in the disclosure of 6α-ethyl-1...

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Detalhes bibliográficos
Main Authors: Pellicciari, Roberto, Gioiello, Antimo, Sabbatini, Paola, Venturoni, Francesco, Nuti, Roberto, Colliva, Carolina, Rizzo, Giovanni, Adorini, Luciano, Pruzanski, Mark, Roda, Aldo, Macchiarulo, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025660/
https://ncbi.nlm.nih.gov/pubmed/24900463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200256d
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