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Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators
[Image: see text] Grounding on our former 3D QSAR studies, a knowledge-based screen of natural bile acids from diverse animal species has led to the identification of avicholic acid as a selective but weak TGR5 agonist. Chemical modifications of this compound resulted in the disclosure of 6α-ethyl-1...
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| Autores principales: | , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American
Chemical Society
2012
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4025660/ https://ncbi.nlm.nih.gov/pubmed/24900463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200256d |
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