Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist

Two dedicated receptors for bile acids (BAs) have been identified, the nuclear hormone receptor farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5, which represent attractive targets for the treatment of metabolic and chronic liver diseases. Previous work characterized 6α-ethyl-3α,7α...

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Detalhes bibliográficos
Main Authors: Rizzo, Giovanni, Passeri, Daniela, De Franco, Francesca, Ciaccioli, Gianmario, Donadio, Loredana, Rizzo, Giorgia, Orlandi, Stefano, Sadeghpour, Bahman, Wang, Xiaoxin X., Jiang, Tao, Levi, Moshe, Pruzanski, Mark, Adorini, Luciano
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981390/
https://ncbi.nlm.nih.gov/pubmed/20631053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.064501
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