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A dual agonist of farnesoid X receptor (FXR) and the G protein–coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice

Even in healthy individuals, renal function gradually declines during aging. However, an observed variation in the rate of this decline has raised the possibility of slowing or delaying age-related kidney disease. One of the most successful interventional measures that slows down and delays age-rela...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Wang, Xiaoxin X., Luo, Yuhuan, Wang, Dong, Adorini, Luciano, Pruzanski, Mark, Dobrinskikh, Evgenia, Levi, Moshe
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5519354/
https://ncbi.nlm.nih.gov/pubmed/28596381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C117.794982
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